Molecular events leading to the creation of a pandemic influenza virus
Identifieur interne : 001068 ( Main/Exploration ); précédent : 001067; suivant : 001069Molecular events leading to the creation of a pandemic influenza virus
Auteurs : Shipra Sharma [Inde] ; Adarsh Mayank [Inde] ; Sunil K. Lal [Inde]Source :
- Indian Journal of Microbiology [ 0046-8991 ] ; 2009.
Abstract
Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.
Url:
DOI: 10.1007/s12088-009-0059-0
PubMed: 23100794
PubMed Central: 3450189
Affiliations:
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Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi, 110067 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>P. O. Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author></analytic><series><title level="j">Indian Journal of Microbiology</title><idno type="ISSN">0046-8991</idno><idno type="eISSN">0973-7715</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. 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